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Heterogeneous clinical responses to histone deacetylase inhibitors (HDACi) in diffuse large B-cell lymphoma (DLBCL) have prompted a need for evaluating the impact of mutations in the histone acetyl transferases (HAT) CREBBP Ray Ban Store Las Vegas and EP300 on HDACi treatment outcome. We identified four DLBCL cell lines; Toledo, with mutations in CREBBP and EP300, SUDHL-7 with mutation of CREBBP and wild-type (wt) EP300, RL with mutation of EP300 and wt CREBBP, and U2932 with wt CREBBP and wt EP300. Vorinostat treatment induced apoptosis significantly more rapid and profound in the CREBBP/EP300 double mutant cell line. Our results suggest that pre-treatment stratification according to HAT defects may be relevant in DLBCL. Arising from discussions at the 1966 Pan-Pacific Science Congress, an account is given of the present situation in respect of conservation areas in New Zealand and its offshore islands, the Kermadec Islands, Norfolk Island, Niue Island, the Fuji Islands, Cook Islands, Tonga Islands, and the Samoan Islands. The Tongan group need urgent study because no biological reports appear to be available for that group. Island conservation has been an important issue in New Zealand for some Ray Ban Aviator Tech time and most of the off-shore islands are now reserves or sanctuaries. A table is given with details of the 42 New Zealand off-shore islands or groups of islands that are considered to be of major importance.