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A class of numerical dissipation models for central-difference schemes constructed with second- and fourth-difference terms is considered. The notion of matrix dissipation associated with upwind schemes is used to establish improved shock capturing capability for these models. In addition, conditions are given that guarantee that such dissipation models produce a TVD scheme. Appropriate switches for this type of model to ensure satisfaction of the TVD property are presented. Significant improvements in the accuracy of a central-difference scheme are demonstrated by computing both inviscid and Buy Ray Bans viscous transonic airfoil flows. The increased migration of peripheral blood mononuclear cells (PBMNCs) across a fibronectin (FN) matrix in response to the chemokines RANTES, MIP-1α and MCP-1 is antagonized by interferon beta-1b (IFNβ-1b). MCP-1 treatment of PBMNCs elevates their mRNA level and secretion of a matrix degrading enzyme, matrix metalloproteinase (MMP)-9, which is abrogated by IFNβ-1b. The clinical benefits of IFNβ-1b treatment in multiple sclerosis patients may in part be a result of this drug's ability to decrease the migration of PBMNCs in spite of Order Ray Ban Online Canada a chemotactic gradient. Furthermore, the elevation of MMP-9 production by PBMNCs may be an important mechanism of action of chemokines.